|
Symbol Name ID |
Smo
smoothened, frizzled class receptor MGI:108075 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Lymphadenopathy |
Hepatosplenomegaly |
| Disease(s) Associated with SMO | ||
| pancreatic cancer |
| Mouse Phenotypes | cardiovascular system phenotype |
abnormal artery morphology |
abnormal sixth pharyngeal arch artery morphology |
pulmonary artery hypoplasia |
abnormal aortic arch morphology |
right aortic arch |
abnormal vitelline vasculature morphology |
blood vessel atresia |
abnormal cardiovascular development |
increased cardiac neural crest cell number |
abnormal cardiac outflow tract development |
persistent truncus arteriosus |
abnormal heart looping |
transposition of great arteries |
atrial septal defect |
ventricular septal defect |
abnormal heart right ventricle morphology |
pericardial edema |
abnormal pericardium morphology |
distended pericardium |
abnormal blood circulation |
hemorrhage |
increased heart rate variability |
decreased heart rate |
prolonged RR interval |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||
| Smobnb/Smobnb | ||||||||||||||||||||||||||
| Smotm1.1Pab/Smotm1.1Pab | ||||||||||||||||||||||||||
| Smotm1Amc/Smotm1Amc | ||||||||||||||||||||||||||
| Smotm1b(KOMP)Wtsi/Smotm1b(KOMP)Wtsi | ||||||||||||||||||||||||||
| Smotm1b(KOMP)Wtsi/Smo+ | ||||||||||||||||||||||||||
| Smotm2Amc/Smotm2Amc Isl1tm1(cre)Tmj/Isl1+ (conditional) |
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| Smotm2Amc/Smotm2Amc Tg(Tek-cre)12Flv/0 (conditional) |
* | |||||||||||||||||||||||||
| Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+ H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Smotm2Amc/Smotm2.1Amc H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Smotm1Amc/Smotm2Amc Isl1tm1(cre)Sev/Isl1+ (conditional) |
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| Smotm2Amc/Smotm2.1Amc Nkx2-5tm1(cre)Rjs/Nkx2-5+ (conditional) |
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| Smotm2Amc/Smotm2.1Amc Tg(Tek-cre)12Flv/0 (conditional) |
* | |||||||||||||||||||||||||
| Smotm2Amc/Smotm2.1Amc Tg(Tnnt2-cre)5Blh/0 (conditional) |
* | |||||||||||||||||||||||||
| Smotm2Amc/Smotm2.1Amc Tg(Mpz-cre)94Imeg/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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